Endocrine Abstracts

Introduction: Hemiballism is a rare hyperkinetic movement disorder characterized by involuntary, violent, coarse and wide-amplitude movements involving the ipsilateral arm and leg. Here, we aimed to present a case diagnosed as hemiballism due to non-ketotic hyperglycemia.Case Report: A 60-year-old female patient presented to the emergency department with involuntary movements in the right half of the trunk for 10 days. It was a large amplitude proximal e...

Introduction: Although ectopic ACTH syndrome (EAS) is most commonly seen in cancers with neuroendocrine differentiation, it is not a common condition in germ cell tumors. Here we report a rare case of EAS due to metastatic germ cell tumor.Case report: A 53-year-old male patient presented with fatigue, weakness, swelling in both legs and weight loss for 3 months. He had type 2 diabetes and no history of smoking or alcohol. In the physical examination, the...

Introduction: Germinomas, which are the most common germ cell tumors of the central nervous system, may present with different symptoms depending on the location and are localized in the 20-30% suprasellar region. Here, we aimed to present a case of suprasellar germinoma with central diabetes insipidus, hypogonadism and secondary adrenal insufficiency.Case Report: A 27-year-old male patient presented with dry mouth, polydipsia, polyuria and nocturia for ...

Objectives: Primary thyroid lymphoma constitutes 0.5-5% of all thyroid malignancies. Its incidence is two per million persons. Patients usually present with rapidly growing masses in the thyroid their sixth-seventh decades. The disease is frequently accompanied by chronic Hashimoto’s thyroiditis. Most tumors are B-cell derived non-Hodgkin’s lymphoma.Case report: An 84-year-old male patient presented with a palpable swelling in the neck. Ultraso...

Introduction: Musculoskeletal system is widely affected in acromegalic patients which might cause difficulties in the diagnosis and treatment of inflammatory rheumatological diseases. Here, we report coexistent rheumatoid arthritis (RA) in three acromegalic patients presenting with continuing joint and back pain although acromegalic state was in remission.Case 1: A 64 years old female patient with acromegaly and macroadenoma had undergone transsphenoidal...

Introduction: Brittle hypertyroidism is a term used for the clinical situation characterized by hypo-hyperthyroidism with antithyroid drugs, despite good compliance and follow-up. Here, we presented five patients suggested to have Brittle Graves.Case-1: Thyrotoxicosis was observed in a 57-year-old female patient and Graves was diagnosed after laboratory and imaging examinations 25 months after initiation of propylthiouracil 50 mg/day, she developed hypot...

Introduction: Rathke’s cleft cyst is one of the pituitary non-adenomatous tumors that found in about 20% of pituitary glands at autopsy. Symptomatic Rathke’s cleft cysts are rarely, but these cysts can cause serious medical problems associated with compression of the pituitary gland, pituitary stalk, optic nerve or hypothalamus. Here, we report a rare case of 73 years old man with sudden onset headache due to Rathke’s cleft cyst present with symptoms and radiolo...

Introduction: Parathyroid lipoadenoma (PLA) is a rarely seen, benign variant of parathyroid adenoma (PA). However, PA usually consists of uniform, polygonal chief cells with a few nests of oxyphil cells, PLA consists of similar histologic features, but with an abundance of fat cells. Additionally, PLA may be functional with the secretion of parathyroid hormone (PTH) or non-functional. Here, we present a case of atypical PLA presented with severe hypercalcemia and skeletal defo...

Introduction: Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) termed as Bethesda Category III constitute 15–30% of thyroid cytology. However, the risk of malignancy in this heterogenous category is estimated as 5–15%. The recent studies has been reported the malignancy rate in the wide range of 6–48%. This causes surgical approach variability between different centers. We aimed to evaluate the initial malignancy rate...

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is associated with neoplasia and hyperfunction of the parathyroid and pituitary glands, pancreatic islet cells, and neuroendocrine cells of the gut. Many authors advocate routine subtotal or total parathyroidectomy and autotransplantation for these patients. Here we demostrate negative MEN1 and MEN4 gene mutation analysis in a case with prolactinoma and a large parathyroid adenoma that could not be localized with preope...